Assay Detail
Functional
CHEMBL5118632
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Antiviral activity against pseudotyped Ebola virus assessed as inhibition of viral entry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebola virus sp. |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.23 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206680 | — | — | 1 | 8.00 |
| CHEMBL4638872 | — | — | 1 | 7.92 |
| CHEMBL4636671 | — | — | 1 | 7.85 |
| CHEMBL4441098 | — | — | 1 | 7.30 |
| CHEMBL2323039 | — | — | 1 | 6.89 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 6.79 |
| CHEMBL4208258 | — | — | 1 | 6.55 |
| CHEMBL5172194 | — | — | 1 | 6.43 |
| CHEMBL4792251 | — | — | 1 | 6.30 |
| CHEMBL5181186 | — | — | 1 | 5.77 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 5.50 |
| CHEMBL1008 | BEPRIDIL | 4.0 | 1 | 5.29 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 5.21 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 5.13 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 5.09 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 4.94 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206680 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4638872 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4636671 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4441098 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2323039 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1655 | TOREMIFENE | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4208258 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5172194 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4792251 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5181186 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL809 | SERTRALINE | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL1008 | BEPRIDIL | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 6240.0 | nM | 5.21 |
| CHEMBL490 | PAROXETINE | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL1201203 | BENZTROPINE | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 13200.0 | nM | 4.88 |