Assay Detail
Binding
CHEMBL5118945
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Inhibition of MMP-2 (unknown origin)
29
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.98 | 10.30 |
| Ki | 12 | 7.54 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473539 | — | — | 1 | 10.30 |
| CHEMBL5174280 | — | — | 1 | 9.69 |
| CHEMBL1801046 | — | — | 1 | 9.66 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 2 | 9.41 |
| CHEMBL5177819 | — | — | 1 | 9.39 |
| CHEMBL5205275 | — | — | 1 | 9.23 |
| CHEMBL100570 | — | — | 1 | 8.42 |
| CHEMBL40143 | — | — | 1 | 8.40 |
| CHEMBL5187653 | — | — | 2 | 8.40 |
| CHEMBL5205063 | — | — | 1 | 8.40 |
| CHEMBL5206844 | — | — | 1 | 8.26 |
| CHEMBL5172839 | — | — | 1 | 8.22 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.22 |
| CHEMBL74539 | — | — | 1 | 7.96 |
| CHEMBL85030 | — | — | 2 | 7.96 |
| CHEMBL445971 | — | — | 1 | 7.80 |
| CHEMBL483857 | — | — | 1 | 7.55 |
| CHEMBL5175662 | — | — | 1 | 7.39 |
| CHEMBL2107228 | SOLIMASTAT | 2.0 | 1 | 7.10 |
| CHEMBL5175770 | — | — | 1 | 6.81 |
| CHEMBL41943 | — | — | 1 | 6.75 |
| CHEMBL485492 | — | — | 1 | 6.08 |
| CHEMBL5184549 | — | — | 1 | 5.62 |
| CHEMBL50228 | — | — | 1 | 5.09 |
| CHEMBL178590 | — | — | 1 | 4.90 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473539 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5174280 | — | IC50 | = | 0.204 | nM | 9.69 |
| CHEMBL1801046 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL19611 | ILOMASTAT | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL5177819 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL5205275 | — | IC50 | = | 0.588 | nM | 9.23 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL100570 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL5205063 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5187653 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL40143 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5187653 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5206844 | — | IC50 | = | 5.51 | nM | 8.26 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5172839 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL85030 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL74539 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL445971 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL85030 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL483857 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL5175662 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2107228 | SOLIMASTAT | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5175770 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL41943 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL485492 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL5184549 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL50228 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL178590 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 56000.0 | nM | 4.25 |