Assay Detail
Binding
CHEMBL5118946
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Inhibition of MMP-3 (unknown origin)
31
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.28 | 9.52 |
| Ki | 12 | 6.59 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473539 | — | — | 1 | 9.52 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 2 | 8.72 |
| CHEMBL1801046 | — | — | 1 | 8.03 |
| CHEMBL5199189 | — | — | 1 | 8.02 |
| CHEMBL85030 | — | — | 2 | 7.89 |
| CHEMBL5198463 | — | — | 1 | 7.76 |
| CHEMBL5205063 | — | — | 1 | 7.70 |
| CHEMBL2107228 | SOLIMASTAT | 2.0 | 1 | 7.52 |
| CHEMBL5187653 | — | — | 2 | 7.52 |
| CHEMBL40143 | — | — | 1 | 7.38 |
| CHEMBL5176328 | — | — | 1 | 7.30 |
| CHEMBL5182668 | — | — | 1 | 7.30 |
| CHEMBL5177819 | — | — | 1 | 6.89 |
| CHEMBL74539 | — | — | 1 | 6.87 |
| CHEMBL5175662 | — | — | 1 | 6.80 |
| CHEMBL5172839 | — | — | 1 | 6.70 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 6.70 |
| CHEMBL34085 | — | — | 1 | 6.58 |
| CHEMBL5175770 | — | — | 1 | 6.28 |
| CHEMBL41943 | — | — | 1 | 5.51 |
| CHEMBL445971 | — | — | 1 | 5.44 |
| CHEMBL483857 | — | — | 1 | 5.40 |
| CHEMBL50228 | — | — | 1 | 4.87 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 4.50 |
| CHEMBL178590 | — | — | 1 | - |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | - |
| CHEMBL485492 | — | — | 1 | - |
| CHEMBL5184549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473539 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1801046 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL5199189 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL85030 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5198463 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL5205063 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL19611 | ILOMASTAT | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL5187653 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5187653 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2107228 | SOLIMASTAT | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL40143 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL85030 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL5176328 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL5182668 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5177819 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL74539 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL5175662 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5172839 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL34085 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL5175770 | — | Ki | = | 527.0 | nM | 6.28 |
| CHEMBL41943 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL445971 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL483857 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL50228 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL485492 | — | Ki | > | 188000.0 | nM | - |
| CHEMBL5184549 | — | Ki | > | 170000.0 | nM | - |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 290000.0 | nM | - |
| CHEMBL178590 | — | IC50 | = | 364000.0 | nM | - |