Assay Detail
Binding
CHEMBL5118947
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Inhibition of MMP-7 (unknown origin)
22
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.75 | 8.30 |
| Ki | 6 | 5.77 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107228 | SOLIMASTAT | 2.0 | 1 | 8.30 |
| CHEMBL5205063 | — | — | 1 | 8.22 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.70 |
| CHEMBL5172839 | — | — | 1 | 7.62 |
| CHEMBL5187653 | — | — | 2 | 7.52 |
| CHEMBL473539 | — | — | 1 | 7.27 |
| CHEMBL5199189 | — | — | 1 | 7.16 |
| CHEMBL5176328 | — | — | 1 | 6.08 |
| CHEMBL1801046 | — | — | 1 | 5.92 |
| CHEMBL5177819 | — | — | 1 | 5.00 |
| CHEMBL178590 | — | — | 1 | 4.85 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 4.55 |
| CHEMBL483857 | — | — | 1 | 4.17 |
| CHEMBL5198463 | — | — | 1 | - |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | - |
| CHEMBL5182668 | — | — | 1 | - |
| CHEMBL40143 | — | — | 1 | - |
| CHEMBL41943 | — | — | 1 | - |
| CHEMBL485492 | — | — | 1 | - |
| CHEMBL445971 | — | — | 1 | - |
| CHEMBL5184549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107228 | SOLIMASTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5205063 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5172839 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5187653 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL473539 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5187653 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL5199189 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5176328 | — | IC50 | = | 825.4 | nM | 6.08 |
| CHEMBL1801046 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5177819 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL178590 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL483857 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL5198463 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5182668 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 125000.0 | nM | - |
| CHEMBL40143 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL41943 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485492 | — | Ki | > | 184000.0 | nM | - |
| CHEMBL445971 | — | Ki | = | 295000.0 | nM | - |
| CHEMBL5184549 | — | Ki | = | 379000.0 | nM | - |