Assay Detail
Binding
CHEMBL5118948
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Inhibition of MMP-8 (unknown origin)
14
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.45 | 8.70 |
| Ki | 6 | 8.59 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 9.74 |
| CHEMBL85030 | — | — | 1 | 8.72 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.70 |
| CHEMBL5187653 | — | — | 2 | 8.52 |
| CHEMBL5175770 | — | — | 1 | 8.40 |
| CHEMBL34085 | — | — | 1 | 8.40 |
| CHEMBL5199189 | — | — | 1 | 8.21 |
| CHEMBL5205063 | — | — | 1 | 8.00 |
| CHEMBL50228 | — | — | 1 | 7.77 |
| CHEMBL5176328 | — | — | 1 | 6.70 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 4.58 |
| CHEMBL5198463 | — | — | 1 | - |
| CHEMBL5182668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL85030 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5187653 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5187653 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5175770 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL34085 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5199189 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5205063 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL50228 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL5176328 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5198463 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5182668 | — | IC50 | > | 500.0 | nM | - |