Assay Detail
Binding
CHEMBL5118950
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Inhibition of MMP-12 (unknown origin)
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.45 | 8.92 |
| Ki | 1 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199189 | — | — | 1 | 8.92 |
| CHEMBL5198463 | — | — | 1 | 8.49 |
| CHEMBL5182668 | — | — | 1 | 8.42 |
| CHEMBL5176328 | — | — | 1 | 8.32 |
| CHEMBL5187653 | — | — | 1 | 8.30 |
| CHEMBL85030 | — | — | 1 | 8.11 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199189 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5198463 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5182668 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5176328 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5187653 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL85030 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL279785 | MARIMASTAT | IC50 | < | 5.0 | nM | - |