Assay Detail
Binding
CHEMBL5118955
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Inhibition of MMP-2 (unknown origin) catalytic activity using Ac-PLG-[2-mercapto-4-methylpentanoyl]-LG-OC2H5 as substrate and measured upto 30 mins by microplate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.91 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199189 | — | — | 1 | 9.52 |
| CHEMBL5182668 | — | — | 1 | 8.89 |
| CHEMBL5198463 | — | — | 1 | 8.85 |
| CHEMBL5176328 | — | — | 1 | 8.77 |
| CHEMBL3359658 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199189 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5182668 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5198463 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5176328 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3359658 | — | IC50 | = | 3.0 | nM | 8.52 |