Assay Detail
Binding
CHEMBL5119804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655950 | — | — | 1 | 6.89 |
| CHEMBL4066043 | — | — | 1 | 5.66 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 5.16 |
| CHEMBL4860333 | — | — | 1 | 4.48 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655950 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4066043 | — | IC50 | = | 2208.0 | nM | 5.66 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL4860333 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | > | 3000.0 | nM | - |