Assay Detail
Binding
CHEMBL5119806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.23 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655950 | — | — | 1 | 8.77 |
| CHEMBL4860333 | — | — | 1 | 8.64 |
| CHEMBL4076426 | — | — | 1 | 8.55 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 8.30 |
| CHEMBL4065147 | — | — | 1 | 7.94 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL4066043 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655950 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4860333 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4076426 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4065147 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4066043 | — | IC50 | = | 25.0 | nM | 7.60 |