Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5120183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HepG2 cells by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug <b>CHNQD-01255</b> with Potent Anti-Hepatocellular Carcinoma Efficacy <i>In Vivo</i>.
Jiang YY, Gao Y, Liu JY, Xu Y, Wei MY, Wang CY, Gu YC, Shao CL.
J Med Chem (2022) 65 : 11970 -11984
PubMed 36089748 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 6.36 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19980 BREFELDIN A 1 7.10
CHEMBL5174852 1 7.00
CHEMBL5201025 1 6.54
CHEMBL5169612 1 6.47
CHEMBL53463 DOXORUBICIN 4.0 1 6.41
CHEMBL5180436 1 6.34
CHEMBL5179051 1 6.19
CHEMBL5196044 1 6.17
CHEMBL5176110 1 6.07
CHEMBL5179187 1 6.03
CHEMBL5186526 1 6.02
CHEMBL5193060 1 6.02
CHEMBL5206820 1 -
CHEMBL5200912 1 -
CHEMBL5182110 1 -
CHEMBL5170233 1 -
CHEMBL5174455 1 -
CHEMBL5186543 1 -
CHEMBL5191202 1 -
CHEMBL5181256 1 -
CHEMBL5192341 1 -
CHEMBL5189771 1 -
CHEMBL5205595 1 -
CHEMBL5201225 1 -
CHEMBL5190080 1 -
CHEMBL5188881 1 -
CHEMBL5203745 1 -
CHEMBL5185173 1 -
CHEMBL5178957 1 -
CHEMBL5181330 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19980 BREFELDIN A IC50 = 80.0 nM 7.10
CHEMBL5174852 IC50 = 100.0 nM 7.00
CHEMBL5201025 IC50 = 290.0 nM 6.54
CHEMBL5169612 IC50 = 340.0 nM 6.47
CHEMBL53463 DOXORUBICIN IC50 = 390.0 nM 6.41
CHEMBL5180436 IC50 = 460.0 nM 6.34
CHEMBL5179051 IC50 = 650.0 nM 6.19
CHEMBL5196044 IC50 = 680.0 nM 6.17
CHEMBL5176110 IC50 = 850.0 nM 6.07
CHEMBL5179187 IC50 = 930.0 nM 6.03
CHEMBL5193060 IC50 = 960.0 nM 6.02
CHEMBL5186526 IC50 = 950.0 nM 6.02
CHEMBL5170004 IC50 > 1000.0 nM -
CHEMBL5179555 IC50 > 1000.0 nM -
CHEMBL1974558 IC50 > 1000.0 nM -
CHEMBL5173728 IC50 > 1000.0 nM -
CHEMBL5206820 IC50 > 1000.0 nM -
CHEMBL5200912 IC50 > 1000.0 nM -
CHEMBL5182110 IC50 > 1000.0 nM -
CHEMBL5170233 IC50 > 1000.0 nM -
CHEMBL5174455 IC50 > 1000.0 nM -
CHEMBL5186543 IC50 > 1000.0 nM -
CHEMBL5191202 IC50 > 1000.0 nM -
CHEMBL5181256 IC50 > 1000.0 nM -
CHEMBL5192341 IC50 > 1000.0 nM -
CHEMBL5189771 IC50 > 1000.0 nM -
CHEMBL5205595 IC50 > 1000.0 nM -
CHEMBL5201225 IC50 > 1000.0 nM -
CHEMBL5190080 IC50 > 1000.0 nM -
CHEMBL5188881 IC50 > 1000.0 nM -
CHEMBL5203745 IC50 > 1000.0 nM -
CHEMBL5185173 IC50 > 1000.0 nM -
CHEMBL5178957 IC50 > 1000.0 nM -
CHEMBL5181330 IC50 > 1000.0 nM -