Assay Detail
Functional
CHEMBL5120184
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Antiproliferative activity against human Bel-7402 cells by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug <b>CHNQD-01255</b> with Potent Anti-Hepatocellular Carcinoma Efficacy <i>In Vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.71 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174852 | — | — | 1 | 7.16 |
| CHEMBL19980 | BREFELDIN A | — | 1 | 7.16 |
| CHEMBL5185173 | — | — | 1 | 6.57 |
| CHEMBL5206820 | — | — | 1 | 6.57 |
| CHEMBL5186526 | — | — | 1 | 6.41 |
| CHEMBL5200912 | — | — | 1 | 6.37 |
| CHEMBL5181330 | — | — | 1 | - |
| CHEMBL1974558 | — | — | 1 | - |
| CHEMBL5182110 | — | — | 1 | - |
| CHEMBL5176110 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174852 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL19980 | BREFELDIN A | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5185173 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5206820 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5186526 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5200912 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5181330 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1974558 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5182110 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5176110 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | > | 1000.0 | nM | - |