Assay Detail
Functional
CHEMBL5121200
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Antiproliferative activity against human MCF7 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.18 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199803 | — | — | 1 | 9.60 |
| CHEMBL5184399 | — | — | 1 | 9.49 |
| CHEMBL5178058 | — | — | 1 | 9.39 |
| CHEMBL5181808 | — | — | 1 | 9.36 |
| CHEMBL5187730 | — | — | 1 | 9.35 |
| CHEMBL5195371 | — | — | 1 | 9.35 |
| CHEMBL5191405 | — | — | 1 | 9.14 |
| CHEMBL5174813 | — | — | 1 | 9.10 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.05 |
| CHEMBL5207726 | — | — | 1 | 9.03 |
| CHEMBL5187253 | — | — | 1 | 8.99 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 8.92 |
| CHEMBL5203282 | — | — | 1 | 8.90 |
| CHEMBL5178110 | — | — | 1 | 8.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199803 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5184399 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5178058 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL5181808 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5187730 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5195371 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5191405 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL5174813 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL5207726 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL5187253 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5203282 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL5178110 | — | IC50 | = | 1.37 | nM | 8.86 |