Assay Detail
Functional
CHEMBL5121206
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Antiproliferative activity against human Ishikawa cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.15 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199803 | — | — | 1 | 9.47 |
| CHEMBL5184399 | — | — | 1 | 9.41 |
| CHEMBL5181808 | — | — | 1 | 9.39 |
| CHEMBL5178058 | — | — | 1 | 9.33 |
| CHEMBL5187730 | — | — | 1 | 9.32 |
| CHEMBL5195371 | — | — | 1 | 9.27 |
| CHEMBL5174813 | — | — | 1 | 9.12 |
| CHEMBL5191405 | — | — | 1 | 9.11 |
| CHEMBL5207726 | — | — | 1 | 9.05 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.03 |
| CHEMBL5187253 | — | — | 1 | 9.02 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 8.90 |
| CHEMBL5203282 | — | — | 1 | 8.85 |
| CHEMBL5178110 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199803 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5184399 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL5181808 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL5178058 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL5187730 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5195371 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL5174813 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL5191405 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5207726 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL5187253 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL5203282 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL5178110 | — | IC50 | = | 1.42 | nM | 8.85 |