Assay Detail
Binding
CHEMBL5121268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARgamma (unknown origin) assessed as increase in fluorescein labeled TRAP220/DRIP-2 coactivator peptide requirement by Lanthascreen TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor γ partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.22 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434063 | — | — | 1 | 8.30 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.82 |
| CHEMBL5188426 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434063 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL408 | TROGLITAZONE | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5188426 | — | EC50 | = | 28800.0 | nM | 4.54 |