Assay Detail
Functional
CHEMBL5121897
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Antimalarial activity against Plasmodium falciparum 3D7 incubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by microdilution method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.59 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1420319 | LIMANTRAFIN | 2.0 | 1 | 6.01 |
| CHEMBL2170943 | — | — | 1 | 5.64 |
| CHEMBL1733474 | — | — | 1 | 5.41 |
| CHEMBL1521758 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1420319 | LIMANTRAFIN | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2170943 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1733474 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1521758 | — | IC50 | = | 5300.0 | nM | 5.28 |