Assay Detail
Binding
CHEMBL5122358
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Binding affinity to GLP-1 receptor (unknown origin) assessed as equlibrium constant by surface plasmon resonance analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of glucagon-like peptide-1 analogs with the C-terminal helix 3 of albumin-binding domain 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.90 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2108724 | SEMAGLUTIDE | 4.0 | 1 | 6.36 |
| CHEMBL5199198 | — | — | 1 | 6.27 |
| CHEMBL5180864 | — | — | 1 | 6.16 |
| CHEMBL5175517 | — | — | 1 | 6.04 |
| CHEMBL5191858 | — | — | 1 | 6.00 |
| CHEMBL5179465 | — | — | 1 | 5.84 |
| CHEMBL5193167 | — | — | 1 | 5.83 |
| CHEMBL5194540 | — | — | 1 | 5.43 |
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2108724 | SEMAGLUTIDE | Kd | = | 441.0 | nM | 6.36 |
| CHEMBL5199198 | — | Kd | = | 532.0 | nM | 6.27 |
| CHEMBL5180864 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL5175517 | — | Kd | = | 912.0 | nM | 6.04 |
| CHEMBL5191858 | — | Kd | = | 994.0 | nM | 6.00 |
| CHEMBL5179465 | — | Kd | = | 1460.0 | nM | 5.84 |
| CHEMBL5193167 | — | Kd | = | 1490.0 | nM | 5.83 |
| CHEMBL5194540 | — | Kd | = | 3750.0 | nM | 5.43 |
| CHEMBL4084119 | LIRAGLUTIDE | Kd | = | 6270.0 | nM | 5.20 |