Assay Detail
Functional
CHEMBL5122833
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Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.24 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191752 | — | — | 1 | 4.47 |
| CHEMBL5170149 | — | — | 1 | 4.30 |
| CHEMBL5194388 | — | — | 1 | 4.28 |
| CHEMBL5174744 | — | — | 1 | 4.26 |
| CHEMBL5187723 | — | — | 1 | 4.24 |
| CHEMBL5175151 | — | — | 1 | 4.24 |
| CHEMBL5170401 | — | — | 1 | 4.23 |
| CHEMBL5172658 | — | — | 1 | 4.19 |
| CHEMBL5206583 | — | — | 1 | 4.17 |
| CHEMBL5204156 | — | — | 1 | 4.12 |
| CHEMBL4174786 | — | — | 1 | 4.09 |
| CHEMBL5183881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191752 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL5170149 | — | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL5194388 | — | IC50 | = | 52060.0 | nM | 4.28 |
| CHEMBL5174744 | — | IC50 | = | 54810.0 | nM | 4.26 |
| CHEMBL5187723 | — | IC50 | = | 57940.0 | nM | 4.24 |
| CHEMBL5175151 | — | IC50 | = | 58180.0 | nM | 4.24 |
| CHEMBL5170401 | — | IC50 | = | 59010.0 | nM | 4.23 |
| CHEMBL5172658 | — | IC50 | = | 64950.0 | nM | 4.19 |
| CHEMBL5206583 | — | IC50 | = | 67540.0 | nM | 4.17 |
| CHEMBL5204156 | — | IC50 | = | 75740.0 | nM | 4.12 |
| CHEMBL4174786 | — | IC50 | = | 81400.0 | nM | 4.09 |
| CHEMBL5183881 | — | IC50 | > | 100000.0 | nM | - |