Assay Detail
Functional
CHEMBL5122963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HGC-27 cells measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.53 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170486 | — | — | 1 | 5.09 |
| CHEMBL5191412 | — | — | 1 | 5.08 |
| CHEMBL5207176 | — | — | 1 | 4.91 |
| CHEMBL5191703 | — | — | 1 | 4.70 |
| CHEMBL5189105 | — | — | 1 | 4.54 |
| CHEMBL5198581 | — | — | 1 | 4.53 |
| CHEMBL5184434 | — | — | 1 | 4.52 |
| CHEMBL5194242 | — | — | 1 | 4.51 |
| CHEMBL5185656 | — | — | 1 | 4.51 |
| CHEMBL5204165 | — | — | 1 | 4.43 |
| CHEMBL5192088 | — | — | 1 | 4.40 |
| CHEMBL5203514 | — | — | 1 | 4.37 |
| CHEMBL5208456 | — | — | 1 | 4.36 |
| CHEMBL5205570 | — | — | 1 | 4.33 |
| CHEMBL5205384 | — | — | 1 | 4.26 |
| CHEMBL5193154 | — | — | 1 | 4.23 |
| CHEMBL5206984 | — | — | 1 | 4.20 |
| CHEMBL5193812 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170486 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL5191412 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL5207176 | — | IC50 | = | 12370.0 | nM | 4.91 |
| CHEMBL5191703 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5189105 | — | IC50 | = | 28940.0 | nM | 4.54 |
| CHEMBL5198581 | — | IC50 | = | 29540.0 | nM | 4.53 |
| CHEMBL5184434 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL5194242 | — | IC50 | = | 30970.0 | nM | 4.51 |
| CHEMBL5185656 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL5204165 | — | IC50 | = | 36780.0 | nM | 4.43 |
| CHEMBL5192088 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5203514 | — | IC50 | = | 42770.0 | nM | 4.37 |
| CHEMBL5208456 | — | IC50 | = | 44060.0 | nM | 4.36 |
| CHEMBL5205570 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL5205384 | — | IC50 | = | 54750.0 | nM | 4.26 |
| CHEMBL5193154 | — | IC50 | = | 58480.0 | nM | 4.23 |
| CHEMBL5206984 | — | IC50 | = | 63550.0 | nM | 4.20 |
| CHEMBL5193812 | — | IC50 | = | 111010.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | > | 150000.0 | nM | - |
| CHEMBL1336 | SORAFENIB | IC50 | > | 150000.0 | nM | - |
| CHEMBL44657 | ETOPOSIDE | IC50 | > | 150000.0 | nM | - |