Assay Detail
Functional
CHEMBL5122965
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Antiproliferative activity against human BGC-823 cells measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BGC-823 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.58 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189105 | — | — | 1 | 4.91 |
| CHEMBL5204165 | — | — | 1 | 4.80 |
| CHEMBL5185656 | — | — | 1 | 4.74 |
| CHEMBL5207176 | — | — | 1 | 4.73 |
| CHEMBL5191412 | — | — | 1 | 4.65 |
| CHEMBL5191703 | — | — | 1 | 4.65 |
| CHEMBL5194242 | — | — | 1 | 4.64 |
| CHEMBL5170486 | — | — | 1 | 4.59 |
| CHEMBL5198581 | — | — | 1 | 4.59 |
| CHEMBL5205384 | — | — | 1 | 4.53 |
| CHEMBL5192088 | — | — | 1 | 4.51 |
| CHEMBL5203514 | — | — | 1 | 4.50 |
| CHEMBL5205570 | — | — | 1 | 4.50 |
| CHEMBL5208456 | — | — | 1 | 4.49 |
| CHEMBL5193154 | — | — | 1 | 4.46 |
| CHEMBL5206984 | — | — | 1 | 4.32 |
| CHEMBL5184434 | — | — | 1 | 4.31 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL5193812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189105 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL5204165 | — | IC50 | = | 15710.0 | nM | 4.80 |
| CHEMBL5185656 | — | IC50 | = | 18020.0 | nM | 4.74 |
| CHEMBL5207176 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL5191412 | — | IC50 | = | 22240.0 | nM | 4.65 |
| CHEMBL5191703 | — | IC50 | = | 22560.0 | nM | 4.65 |
| CHEMBL5194242 | — | IC50 | = | 22670.0 | nM | 4.64 |
| CHEMBL5170486 | — | IC50 | = | 25740.0 | nM | 4.59 |
| CHEMBL5198581 | — | IC50 | = | 25450.0 | nM | 4.59 |
| CHEMBL5205384 | — | IC50 | = | 29540.0 | nM | 4.53 |
| CHEMBL5192088 | — | IC50 | = | 30570.0 | nM | 4.51 |
| CHEMBL5203514 | — | IC50 | = | 31870.0 | nM | 4.50 |
| CHEMBL5205570 | — | IC50 | = | 31780.0 | nM | 4.50 |
| CHEMBL5208456 | — | IC50 | = | 32540.0 | nM | 4.49 |
| CHEMBL5193154 | — | IC50 | = | 34410.0 | nM | 4.46 |
| CHEMBL5206984 | — | IC50 | = | 47410.0 | nM | 4.32 |
| CHEMBL5184434 | — | IC50 | = | 49060.0 | nM | 4.31 |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - | |
| CHEMBL1336 | SORAFENIB | IC50 | - | — | - | |
| CHEMBL65 | CAMPTOTHECIN | IC50 | - | — | - | |
| CHEMBL5193812 | — | IC50 | > | 150000.0 | nM | - |