Assay Detail
Functional
CHEMBL5122969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.40 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207176 | — | — | 1 | 4.64 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.61 |
| CHEMBL5208456 | — | — | 1 | 4.61 |
| CHEMBL5191412 | — | — | 1 | 4.55 |
| CHEMBL5204165 | — | — | 1 | 4.55 |
| CHEMBL5191703 | — | — | 1 | 4.50 |
| CHEMBL5184434 | — | — | 1 | 4.43 |
| CHEMBL5170486 | — | — | 1 | 4.39 |
| CHEMBL5205570 | — | — | 1 | 4.30 |
| CHEMBL5189105 | — | — | 1 | 4.29 |
| CHEMBL5193154 | — | — | 1 | 4.27 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.19 |
| CHEMBL5198581 | — | — | 1 | 4.15 |
| CHEMBL5192088 | — | — | 1 | 4.12 |
| CHEMBL5193812 | — | — | 1 | - |
| CHEMBL5203514 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL5205384 | — | — | 1 | - |
| CHEMBL5206984 | — | — | 1 | - |
| CHEMBL5194242 | — | — | 1 | - |
| CHEMBL5185656 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207176 | — | IC50 | = | 22910.0 | nM | 4.64 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 24310.0 | nM | 4.61 |
| CHEMBL5208456 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL5191412 | — | IC50 | = | 28290.0 | nM | 4.55 |
| CHEMBL5204165 | — | IC50 | = | 27930.0 | nM | 4.55 |
| CHEMBL5191703 | — | IC50 | = | 31720.0 | nM | 4.50 |
| CHEMBL5184434 | — | IC50 | = | 37530.0 | nM | 4.43 |
| CHEMBL5170486 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL5205570 | — | IC50 | = | 50630.0 | nM | 4.30 |
| CHEMBL5189105 | — | IC50 | = | 51840.0 | nM | 4.29 |
| CHEMBL5193154 | — | IC50 | = | 53630.0 | nM | 4.27 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL5198581 | — | IC50 | = | 71480.0 | nM | 4.15 |
| CHEMBL5192088 | — | IC50 | = | 76220.0 | nM | 4.12 |
| CHEMBL5193812 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL5203514 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | < | 1850.0 | nM | - |
| CHEMBL5205384 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL5206984 | — | IC50 | = | 144510.0 | nM | - |
| CHEMBL5194242 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL5185656 | — | IC50 | = | 106640.0 | nM | - |