Assay Detail
Binding
CHEMBL5123055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction assessed as equilibrium dissociation constant using FITC-betaAla-DEETGEF-OH as fluorescent probe substrate incubated for 60 mins by fluorescent anisotropy assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 5.54 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235901 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235901 | — | Kd | = | 2900.0 | nM | 5.54 |