Assay Detail
Binding
CHEMBL5123365
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Inhibition of CDK1/Cyclin B (unknown origin)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.26 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196505 | — | — | 1 | 10.10 |
| CHEMBL5178317 | — | — | 1 | 9.96 |
| CHEMBL5176598 | — | — | 1 | 9.89 |
| CHEMBL5207372 | — | — | 1 | 9.01 |
| CHEMBL5190531 | — | — | 1 | 8.96 |
| CHEMBL5198209 | — | — | 1 | 8.96 |
| CHEMBL5185047 | — | — | 1 | 8.96 |
| CHEMBL5193072 | — | — | 1 | 8.92 |
| CHEMBL4650328 | AVOTACICLIB | 1.0 | 1 | 8.82 |
| CHEMBL5178590 | — | — | 1 | 8.77 |
| CHEMBL384304 | RG-547 | 2.0 | 1 | 8.70 |
| CHEMBL5209261 | — | — | 1 | 8.64 |
| CHEMBL5192603 | — | — | 1 | 8.60 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.52 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.15 |
| CHEMBL48362 | — | — | 1 | 8.05 |
| CHEMBL5183999 | — | — | 1 | 7.92 |
| CHEMBL216126 | — | — | 1 | 7.55 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.52 |
| CHEMBL4741442 | — | — | 1 | 7.30 |
| CHEMBL1208600 | — | — | 1 | 7.26 |
| CHEMBL51709 | — | — | 1 | 7.22 |
| CHEMBL5174787 | — | — | 1 | 7.07 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 6.68 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196505 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5178317 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5176598 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5207372 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL5190531 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5198209 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5185047 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5193072 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4650328 | AVOTACICLIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5178590 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL384304 | RG-547 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5209261 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5192603 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL48362 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5183999 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL216126 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4741442 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1208600 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL51709 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5174787 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL445813 | AT-7519 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 10000.0 | nM | 5.00 |