Assay Detail
Binding
CHEMBL5123367
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Inhibition of CDK2/Cyclin E (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.37 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51709 | — | — | 1 | 9.51 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 9.00 |
| CHEMBL5196505 | — | — | 1 | 8.97 |
| CHEMBL5201870 | TEGTOCICLIB | 2.0 | 1 | 8.94 |
| CHEMBL4650328 | AVOTACICLIB | 1.0 | 1 | 8.82 |
| CHEMBL5176598 | — | — | 1 | 8.68 |
| CHEMBL5178317 | — | — | 1 | 8.68 |
| CHEMBL384304 | RG-547 | 2.0 | 1 | 8.52 |
| CHEMBL4741442 | — | — | 1 | 8.40 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.05 |
| CHEMBL216126 | — | — | 1 | 7.62 |
| CHEMBL48362 | — | — | 1 | 7.52 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 7.42 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51709 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5196505 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL5201870 | TEGTOCICLIB | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL4650328 | AVOTACICLIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5176598 | — | IC50 | = | 2.11 | nM | 8.68 |
| CHEMBL5178317 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL384304 | RG-547 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4741442 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL216126 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL48362 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 100.0 | nM | 7.00 |