Assay Detail
Binding
CHEMBL5123369
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Inhibition of CDK6/Cyclin D (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3904602 | LEROCICLIB | 3.0 | 1 | 8.70 |
| CHEMBL3894860 | TRILACICLIB | 4.0 | 1 | 8.40 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 8.00 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 7.80 |
| CHEMBL4802161 | DALPICICLIB | 3.0 | 1 | 7.75 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 7.41 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.22 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 6.77 |
| CHEMBL4650328 | AVOTACICLIB | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3904602 | LEROCICLIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3894860 | TRILACICLIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4802161 | DALPICICLIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL445813 | AT-7519 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4650328 | AVOTACICLIB | IC50 | > | 200.0 | nM | - |