Assay Detail

CHEMBL5123377

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of bovine brain CDK5/p25 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bos taurus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.

Shi Z, Tian L, Qiang T, Li J, Xing Y, Ren X, Liu C, Liang C.
J Med Chem (2022) 65 : 6390 -6418
PubMed 35485642 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.80	9.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL14762	SELICICLIB	2.0	1	9.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL14762	SELICICLIB	IC50	=	0.16	nM	9.80