Assay Detail
Binding
CHEMBL5123485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by HTRF analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of indirubin-3'-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.91 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195819 | — | — | 1 | 9.74 |
| CHEMBL5201185 | — | — | 1 | 9.74 |
| CHEMBL5170345 | — | — | 1 | 9.70 |
| CHEMBL5188834 | — | — | 1 | 9.70 |
| CHEMBL5188978 | — | — | 1 | 9.70 |
| CHEMBL5209537 | — | — | 1 | 9.66 |
| CHEMBL1623035 | — | — | 1 | 9.49 |
| CHEMBL5202926 | — | — | 1 | 9.46 |
| CHEMBL5195070 | — | — | 1 | 9.41 |
| CHEMBL5170760 | — | — | 1 | 9.35 |
| CHEMBL5199328 | — | — | 1 | 9.28 |
| CHEMBL5173987 | — | — | 1 | 9.16 |
| CHEMBL5186291 | — | — | 1 | 9.12 |
| CHEMBL5186183 | — | — | 1 | 8.97 |
| CHEMBL5195353 | — | — | 1 | 8.95 |
| CHEMBL5181917 | — | — | 1 | 8.87 |
| CHEMBL5200813 | — | — | 1 | 8.79 |
| CHEMBL5169874 | — | — | 1 | 8.79 |
| CHEMBL5181019 | — | — | 1 | 8.72 |
| CHEMBL5169937 | — | — | 1 | 8.67 |
| CHEMBL5172103 | — | — | 1 | 8.66 |
| CHEMBL5201194 | — | — | 1 | 8.57 |
| CHEMBL5187737 | — | — | 1 | 8.54 |
| CHEMBL5182954 | — | — | 1 | 8.51 |
| CHEMBL5196786 | — | — | 1 | 8.49 |
| CHEMBL5185448 | — | — | 1 | 8.47 |
| CHEMBL5202099 | — | — | 1 | 8.46 |
| CHEMBL5207101 | — | — | 1 | 8.42 |
| CHEMBL5182860 | — | — | 1 | 7.84 |
| CHEMBL5192189 | — | — | 1 | 7.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195819 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL5201185 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL5170345 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5188834 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5188978 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5209537 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL1623035 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5202926 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5195070 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL5170760 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5199328 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL5173987 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL5186291 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5186183 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5195353 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL5181917 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL5200813 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL5169874 | — | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL5181019 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL5169937 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL5172103 | — | IC50 | = | 2.19 | nM | 8.66 |
| CHEMBL5201194 | — | IC50 | = | 2.71 | nM | 8.57 |
| CHEMBL5187737 | — | IC50 | = | 2.89 | nM | 8.54 |
| CHEMBL5182954 | — | IC50 | = | 3.07 | nM | 8.51 |
| CHEMBL5196786 | — | IC50 | = | 3.25 | nM | 8.49 |
| CHEMBL5185448 | — | IC50 | = | 3.41 | nM | 8.47 |
| CHEMBL5202099 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL5207101 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL5182860 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL5192189 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL5182679 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL5191315 | — | IC50 | > | 50.0 | nM | - |