Assay Detail
Functional
CHEMBL5123554
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Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.48 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391533 | COROSOLIC ACID | — | 1 | 4.98 |
| CHEMBL239077 | TOMENTIC ACID | — | 1 | 4.63 |
| CHEMBL486986 | POMOLIC ACID | — | 1 | 4.29 |
| CHEMBL230128 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391533 | COROSOLIC ACID | IC50 | = | 10510.0 | nM | 4.98 |
| CHEMBL239077 | TOMENTIC ACID | IC50 | = | 23240.0 | nM | 4.63 |
| CHEMBL486986 | POMOLIC ACID | IC50 | = | 51550.0 | nM | 4.29 |
| CHEMBL230128 | — | IC50 | = | 96450.0 | nM | 4.02 |