Assay Detail
Functional
CHEMBL5123556
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Reversal of platinum resistance in cisplatin-resistant human SK-OV-3 cells assessed as reduction in cisplatin IC50 after 48 hrs in presence of cisplatin by SRB assay (Rvb = 28.23 microM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.08 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239077 | TOMENTIC ACID | — | 1 | 5.62 |
| CHEMBL486986 | POMOLIC ACID | — | 1 | 5.43 |
| CHEMBL230128 | — | — | 1 | 4.67 |
| CHEMBL391533 | COROSOLIC ACID | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239077 | TOMENTIC ACID | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL486986 | POMOLIC ACID | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL230128 | — | IC50 | = | 21470.0 | nM | 4.67 |
| CHEMBL391533 | COROSOLIC ACID | IC50 | = | 26420.0 | nM | 4.58 |