Assay Detail
Functional
CHEMBL5123573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.97 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186967 | — | — | 1 | 6.23 |
| CHEMBL5200521 | — | — | 1 | 6.02 |
| CHEMBL5181947 | — | — | 1 | 5.82 |
| CHEMBL5200358 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186967 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5200521 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5181947 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5200358 | — | EC50 | = | 1600.0 | nM | 5.80 |