Assay Detail
Binding
CHEMBL5123579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP10 in human HeLa cells assessed as increase in cell colonies incubated for 10 days with replacement with fresh medium for every 4 days by methylene blue dye based colony formation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP10 (CHEMBL2429708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.87 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1438938 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1438938 | — | IC50 | = | 1350.0 | nM | 5.87 |