Assay Detail
Binding
CHEMBL5123598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of human recombinant LDHA assessed as inhibition constant using varying concentration of pyruvate as substrate preincubated for 10 mins followed by substrate addition and measured every 60 sec for 10 mins in the presence of NADH by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.04 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180187 | — | — | 1 | 7.05 |
| CHEMBL5182027 | — | — | 1 | 6.05 |
| CHEMBL4247590 | — | — | 1 | 5.85 |
| CHEMBL5190607 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180187 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL5182027 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4247590 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL5190607 | — | Ki | = | 6100.0 | nM | 5.21 |