Assay Detail
Binding
CHEMBL5123804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LSD1/CoREST using histone H3 peptide as substrate by fluorescence polarization assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.77 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134377 | — | — | 1 | 7.46 |
| CHEMBL5202637 | — | — | 1 | 6.97 |
| CHEMBL5170197 | — | — | 1 | 6.84 |
| CHEMBL5179091 | — | — | 1 | 6.83 |
| CHEMBL5198334 | — | — | 1 | 6.82 |
| CHEMBL5178765 | — | — | 1 | 6.81 |
| CHEMBL5175171 | — | — | 1 | 6.77 |
| CHEMBL5186174 | — | — | 1 | 6.76 |
| CHEMBL5181017 | — | — | 1 | 6.74 |
| CHEMBL5205888 | — | — | 1 | 6.69 |
| CHEMBL5204694 | — | — | 1 | 6.67 |
| CHEMBL1232432 | — | — | 1 | 6.36 |
| CHEMBL5189687 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134377 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL5202637 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL5170197 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL5179091 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL5198334 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL5178765 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL5175171 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL5186174 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL5181017 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL5205888 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL5204694 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL1232432 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL5189687 | — | Ki | = | 569.0 | nM | 6.25 |