Assay Detail
Functional
CHEMBL5123830
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.01 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178765 | — | — | 1 | 6.68 |
| CHEMBL5170197 | — | — | 1 | 6.54 |
| CHEMBL5202637 | — | — | 1 | 6.40 |
| CHEMBL5179091 | — | — | 1 | 6.10 |
| CHEMBL1232432 | — | — | 1 | 5.80 |
| CHEMBL5189687 | — | — | 1 | 5.62 |
| CHEMBL5198334 | — | — | 1 | 5.47 |
| CHEMBL1231795 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178765 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5170197 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5202637 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5179091 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1232432 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5189687 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL5198334 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1231795 | — | IC50 | = | 3560.0 | nM | 5.45 |