Assay Detail

CHEMBL5123976

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiproliferative activity against human NCI-H1299 cells

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

NCI-H1299 (CHEMBL612255) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

NCI-H1299 (CHEMBL612255) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H1299

CHEMBL612255

Anchored from Assay target.

Protein identity NCI-H1299

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H1299
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H1299 (CHEMBL612255) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects.

Xia J, Li J, Tian L, Ren X, Liu C, Liang C.
J Med Chem (2022) 65 : 7016 -7043
PubMed 35531606 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.68	6.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL154745	—	—	1	6.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL154745	—	IC50	=	210.0	nM	6.68