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Assay Detail

CHEMBL5124202

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [I125I]AngII form pig AT2 receptor myometrial membrane incubated for 1.5 hrs by gamma counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Tissue Uterus
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Angiotensin type II receptor (CHEMBL1163122)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds.
Gopalan G, Palo-Nieto C, Petersen NN, Hallberg M, Larhed M.
Bioorg Med Chem (2022) 65 : 116790 -116790
PubMed 35550979 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 8.98 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL189568 BULOXIBUTID 0.5 1 9.40
CHEMBL288174 1 8.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL189568 BULOXIBUTID Ki = 0.4 nM 9.40
CHEMBL288174 Ki = 2.8 nM 8.55