Assay Detail
Functional
CHEMBL5124225
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Antiproliferative activity against human HeLa cells incubated for 24 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.79 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 7.22 |
| CHEMBL5204766 | — | — | 1 | 5.26 |
| CHEMBL5204078 | — | — | 1 | 4.88 |
| CHEMBL5177761 | — | — | 1 | - |
| CHEMBL5185256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5204766 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5204078 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5177761 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5185256 | — | IC50 | > | 100000.0 | nM | - |