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Assay Detail

CHEMBL5124408

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Functional
Antiviral activity against MHV by cell based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Murine hepatitis virus
Confidence 1 — Organism
Curated By Autocuration

Target

Murine hepatitis virus (CHEMBL613733)
Type ORGANISM
Organism Murine hepatitis virus

Publication

Peptidomimetics: An Overview of Recent Medicinal Chemistry Efforts toward the Discovery of Novel Small Molecule Inhibitors.
Li Petri G, Di Martino S, De Rosa M.
J Med Chem (2022) 65 : 7438 -7475
PubMed 35604326 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 6.82 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5190394 1 7.10
CHEMBL5174145 1 7.10
CHEMBL5184284 1 6.96
CHEMBL5195656 1 6.92
CHEMBL5178275 1 6.92
CHEMBL5194912 1 6.89
CHEMBL5188945 1 6.89
CHEMBL5172701 1 6.80
CHEMBL5173283 1 6.80
CHEMBL5175540 1 6.70
CHEMBL2315036 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5190394 EC50 = 80.0 nM 7.10
CHEMBL5174145 EC50 = 80.0 nM 7.10
CHEMBL5184284 EC50 = 110.0 nM 6.96
CHEMBL5195656 EC50 = 120.0 nM 6.92
CHEMBL5178275 EC50 = 120.0 nM 6.92
CHEMBL5194912 EC50 = 130.0 nM 6.89
CHEMBL5188945 EC50 = 130.0 nM 6.89
CHEMBL5172701 EC50 = 160.0 nM 6.80
CHEMBL5173283 EC50 = 160.0 nM 6.80
CHEMBL5175540 EC50 = 200.0 nM 6.70
CHEMBL2315036 EC50 = 1100.0 nM 5.96