Assay Detail
Functional
CHEMBL5124457
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Silencing Tautomerization to Isolate Unstable Physalins from <i>Physalis minima</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.29 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177640 | — | — | 1 | 6.70 |
| CHEMBL5198674 | — | — | 1 | 5.70 |
| CHEMBL5177559 | — | — | 1 | 5.38 |
| CHEMBL5200872 | — | — | 1 | 5.37 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.36 |
| CHEMBL5181890 | — | — | 1 | 5.27 |
| CHEMBL5196803 | — | — | 1 | 5.16 |
| CHEMBL5173888 | — | — | 1 | 5.05 |
| CHEMBL5184046 | — | — | 1 | 4.94 |
| CHEMBL504404 | PHYSALIN B | — | 1 | 4.92 |
| CHEMBL5204565 | — | — | 1 | 4.91 |
| CHEMBL5175225 | — | — | 1 | 4.66 |
| CHEMBL5203759 | — | — | 1 | - |
| CHEMBL5200787 | — | — | 1 | - |
| CHEMBL5199906 | — | — | 1 | - |
| CHEMBL5208941 | — | — | 1 | - |
| CHEMBL5171523 | — | — | 1 | - |
| CHEMBL5190130 | — | — | 1 | - |
| CHEMBL5190947 | — | — | 1 | - |
| CHEMBL4851096 | — | — | 1 | - |
| CHEMBL5195529 | — | — | 1 | - |
| CHEMBL504910 | — | — | 1 | - |
| CHEMBL5181057 | — | — | 1 | - |
| CHEMBL1835434 | PHYSALIN G | — | 1 | - |
| CHEMBL5176322 | — | — | 1 | - |
| CHEMBL5182035 | — | — | 1 | - |
| CHEMBL5170466 | — | — | 1 | - |
| CHEMBL5200537 | — | — | 1 | - |
| CHEMBL5181567 | — | — | 1 | - |
| CHEMBL5180180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177640 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5198674 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5177559 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5200872 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5181890 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5196803 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5173888 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5184046 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL504404 | PHYSALIN B | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5204565 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5175225 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL5205019 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5172878 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5207644 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5203759 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5200787 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5199906 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5208941 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5171523 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5190130 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5190947 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4851096 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5195529 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL504910 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5181057 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1835434 | PHYSALIN G | IC50 | > | 50000.0 | nM | - |
| CHEMBL5176322 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5182035 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5170466 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5200537 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5181567 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5180180 | — | IC50 | > | 50000.0 | nM | - |