Assay Detail
Binding
CHEMBL5124476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal his-tagged human PARP10 expressed in Escherichia coli Rosette2 (DE3)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP10 (CHEMBL2429708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.88 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126054 | — | — | 1 | 6.32 |
| CHEMBL5184823 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126054 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5184823 | — | IC50 | = | 3640.0 | nM | 5.44 |