Assay Detail
Functional
CHEMBL5124483
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Cytoprotective activity against human HeLa cells assessed as rescue of PARP10-induced cell death by measuring number of colonies treated for 8 to 10 days followed by compound replenishment for every 3 days by methylene blue staining based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.76 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184823 | — | — | 1 | 5.77 |
| CHEMBL4126054 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184823 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4126054 | — | IC50 | = | 1800.0 | nM | 5.75 |