Assay Detail
Binding
CHEMBL5124486
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Displacement of [3H]NAD+ from GST-tagged PARP14 (unknown origin) incubated for 210 mins by radiometric assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP14 (CHEMBL2176777) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.38 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196898 | — | — | 1 | 6.51 |
| CHEMBL5199759 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196898 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5199759 | — | IC50 | = | 580.0 | nM | 6.24 |