Assay Detail
Binding
CHEMBL5124487
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Inhibition of PARP14 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP14 (CHEMBL2176777) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.36 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180081 | — | — | 1 | 8.00 |
| CHEMBL5171039 | — | — | 1 | 7.72 |
| CHEMBL5178541 | — | — | 1 | 7.12 |
| CHEMBL5191979 | — | — | 1 | 6.21 |
| CHEMBL5207717 | — | — | 1 | 6.04 |
| CHEMBL5187963 | — | — | 1 | 5.89 |
| CHEMBL5095043 | ATAMPARIB | 1.0 | 1 | 5.64 |
| CHEMBL5191676 | — | — | 1 | 5.54 |
| CHEMBL5186007 | — | — | 1 | 5.07 |
| CHEMBL5176622 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180081 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5171039 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5178541 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5191979 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5207717 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL5187963 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5095043 | ATAMPARIB | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5191676 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL5186007 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL5176622 | — | IC50 | - | — | - |