Assay Detail
Binding
CHEMBL5124488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP14 (unknown origin) by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP14 (CHEMBL2176777) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.01 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179405 | — | — | 1 | 8.52 |
| CHEMBL5180051 | — | — | 1 | 6.52 |
| CHEMBL5177845 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179405 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5180051 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5177845 | — | IC50 | = | 1000.0 | nM | 6.00 |