Assay Detail
Binding
CHEMBL5124490
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Inhibition of PARP1 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.77 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095043 | ATAMPARIB | 1.0 | 1 | 7.43 |
| CHEMBL5187963 | — | — | 1 | 6.10 |
| CHEMBL5191676 | — | — | 1 | - |
| CHEMBL5186007 | — | — | 1 | - |
| CHEMBL5207717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095043 | ATAMPARIB | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5187963 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5191676 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5186007 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5207717 | — | IC50 | > | 30000.0 | nM | - |