Assay Detail
Binding
CHEMBL5124491
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Inhibition of PARP2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.78 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095043 | ATAMPARIB | 1.0 | 1 | 7.77 |
| CHEMBL5187963 | — | — | 1 | 4.80 |
| CHEMBL5186007 | — | — | 1 | 4.76 |
| CHEMBL5191676 | — | — | 1 | - |
| CHEMBL5207717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095043 | ATAMPARIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5187963 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5186007 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL5191676 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5207717 | — | IC50 | > | 30000.0 | nM | - |