Assay Detail
Functional
CHEMBL5124546
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Immunosuppressive activity in BALB/c mouse splenocytes assessed as reduction in LPS-induced mouse B-lymphocytes proliferation incubated for 8 hrs by beta scintillation counting based [3H]thymidine incorporation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dolabrane-Type Diterpenoids with Immunosuppressive Activity from <i>Koilodepas hainanense</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.69 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5202789 | — | — | 1 | 6.54 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.13 |
| CHEMBL5205000 | — | — | 1 | 5.65 |
| CHEMBL517524 | — | — | 1 | 5.52 |
| CHEMBL5172008 | — | — | 1 | 5.33 |
| CHEMBL5183271 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5202789 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5205000 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL517524 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL5172008 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL5183271 | — | IC50 | = | 10250.0 | nM | 4.99 |