Assay Detail
Functional
CHEMBL5125682
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Antiproliferative activity against human JJN-3R cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JJN-3R |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.17 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5209210 | — | — | 1 | 8.52 |
| CHEMBL4297458 | EZOBRESIB | 2.0 | 1 | 8.44 |
| CHEMBL5207310 | — | — | 1 | 8.40 |
| CHEMBL5204989 | — | — | 1 | 8.30 |
| CHEMBL5209351 | — | — | 1 | 8.30 |
| CHEMBL4077176 | — | — | 1 | 8.30 |
| CHEMBL4859923 | — | — | 1 | 8.22 |
| CHEMBL5185824 | — | — | 1 | 8.22 |
| CHEMBL5189057 | — | — | 1 | 8.15 |
| CHEMBL5206537 | — | — | 1 | 8.15 |
| CHEMBL5201345 | — | — | 1 | 8.05 |
| CHEMBL5171108 | — | — | 1 | 8.00 |
| CHEMBL5179686 | — | — | 1 | 7.89 |
| CHEMBL5172933 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5209210 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4297458 | EZOBRESIB | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5207310 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5204989 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5209351 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4077176 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4859923 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5185824 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5189057 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5206537 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5201345 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5171108 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5179686 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5172933 | — | IC50 | = | 39.0 | nM | 7.41 |