Assay Detail
Binding
CHEMBL5125833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation activity using peptide substrate in presence of ATP and measured after 1 hrs by HTRF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bone morphogenetic protein receptor type-1A (CHEMBL5275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.23 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184000 | — | — | 1 | 6.60 |
| CHEMBL5186341 | — | — | 1 | 6.42 |
| CHEMBL5199417 | — | — | 1 | 6.27 |
| CHEMBL5181536 | — | — | 1 | 6.04 |
| CHEMBL5181872 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184000 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL5186341 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL5199417 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL5181536 | — | IC50 | = | 901.0 | nM | 6.04 |
| CHEMBL5181872 | — | IC50 | = | 1515.0 | nM | 5.82 |