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Assay Detail

CHEMBL5126487

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against SARS-CoV-2 infected in African green monkey VeroE6 cells expressing TMPRSS2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Severe acute respiratory syndrome coronavirus 2
Confidence 1 — Organism
Curated By Autocuration

Target

SARS-CoV-2 (CHEMBL4303835)
Type ORGANISM
Organism Severe acute respiratory syndrome coronavirus 2

Publication

Oral Nonpeptidic, Noncovalent Triazine Coronavirus Main Protease Inhibitors for Treating COVID-19.
Chia CSB, Inoue M.
ACS Med Chem Lett (2022) 13 : 1394 -1396
PubMed 36105344 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 6.14 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5195764 1 7.46
CHEMBL5196584 1 6.88
CHEMBL5187177 1 6.75
CHEMBL5188818 1 6.70
CHEMBL5197155 1 6.49
CHEMBL5183847 ENSITRELVIR 3.0 1 6.48
CHEMBL5201925 1 6.47
CHEMBL5185732 1 6.42
CHEMBL5192777 1 6.40
CHEMBL5207127 1 6.35
CHEMBL5194350 1 6.27
CHEMBL5200024 1 6.17
CHEMBL5208498 1 6.12
CHEMBL5206128 1 6.12
CHEMBL5177083 1 5.99
CHEMBL5192363 1 5.82
CHEMBL5208006 1 5.23
CHEMBL5188525 1 5.18
CHEMBL5203047 1 4.94
CHEMBL5203920 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5195764 EC50 = 35.0 nM 7.46
CHEMBL5196584 EC50 = 131.0 nM 6.88
CHEMBL5187177 EC50 = 177.0 nM 6.75
CHEMBL5188818 EC50 = 201.0 nM 6.70
CHEMBL5197155 EC50 = 321.0 nM 6.49
CHEMBL5183847 ENSITRELVIR EC50 = 328.0 nM 6.48
CHEMBL5201925 EC50 = 342.0 nM 6.47
CHEMBL5185732 EC50 = 385.0 nM 6.42
CHEMBL5192777 EC50 = 395.0 nM 6.40
CHEMBL5207127 EC50 = 450.0 nM 6.35
CHEMBL5194350 EC50 = 533.0 nM 6.27
CHEMBL5200024 EC50 = 680.0 nM 6.17
CHEMBL5208498 EC50 = 750.0 nM 6.12
CHEMBL5206128 EC50 = 750.0 nM 6.12
CHEMBL5177083 EC50 = 1030.0 nM 5.99
CHEMBL5192363 EC50 = 1520.0 nM 5.82
CHEMBL5208006 EC50 = 5850.0 nM 5.23
CHEMBL5188525 EC50 = 6600.0 nM 5.18
CHEMBL5203047 EC50 = 11500.0 nM 4.94
CHEMBL5203920 EC50 = 22500.0 nM 4.65