Assay Detail
Functional
CHEMBL5126689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells assessed as reduction in viral plaques by plaque reduction assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.72 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427166 | — | — | 1 | 6.05 |
| CHEMBL4851462 | — | — | 1 | 6.05 |
| CHEMBL5208639 | — | — | 1 | 5.82 |
| CHEMBL5170425 | — | — | 1 | 5.66 |
| CHEMBL5190756 | — | — | 1 | 5.58 |
| CHEMBL5185160 | — | — | 1 | 5.57 |
| CHEMBL5204224 | — | — | 1 | 5.32 |
| CHEMBL5180730 | — | — | 1 | - |
| CHEMBL5189649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427166 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4851462 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5208639 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5170425 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5190756 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5185160 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5204224 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5180730 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5189649 | — | EC50 | > | 10000.0 | nM | - |